10.

Wynn JE, Van't Riet B, Borzelleca JF (Med. Coll. of Virginia). Toxicity and pharmaco-dynamics of EGTA: oral administration to rats and comparisons with EDTA. Toxicol Appl Pharmacol. 1970; 16(3):807-817. (CA73) [The clin. application of an agent that has the ability to chelate Ca more specifically than it does Mg would be desirable. Such an agent, ethylene glycol bis-(b-aminoethylether)-N,N,N1,N1-tetraacetic acid (EGTA) was evaluated in rats. Acute and subchronic oral toxicities were detd. In addn., absorption and excretion characteristics were investigated. The acute oral LD50 for Na2H2EGTA in male Holtzman rats was 9.43 millimoles/kg compared to 6.25 millimoles/kg reported for Na2h2edta. In subchronic studies, EGTA was compared directly to EDTA by feeding up to 10% by wt. of the di-N salt of each agent in the regular chow for 90 days. Both EDTA and EGTA were absorbed to the extent of <5% of the subchronic dose. Recovery of these substances from the urine and feces ruled out significant metabolism. The proportion of Ca not bound to chelate decreased a the amt. of dietary chelate increased. EGTA was better tolerated in the diet and appeared to be less irritating and less toxic than EDTA.]

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