3.

Vasil'eva OG. (Inst Ind Hyg Occup Dis, Acad Med Sci, USSR) Side effects of CaNa2 ethylene-diaminetetraacetate in experimental lead intoxication. Gigiena 1 Sanitariya. 1961;26:22-5 (Mar.). (979) [Ten of 30 guinea pigs received daily oral doses of Pb (as Pb nitrate) of 45 mg/kg; 10 received in addition 2 ml 10% CaNa2EDTA orally; 10 served as controls. Urinary and fecal Pb was followed, using the chromate method. Pb content in bone was also determined. The duration of treatment was apparently 4 wk. Orally administered EDTA resulted in increased urinary and decreased fecal excretion of Pb; Pb concentration in bones increased, causing aggravation of Pb poisoning. Of 10 animals in the EDTA group, 6 died during the experiment. Upon necropsy, aside from other findings, fatty degeneration of the liver was seen.
In another experiment, the effect of EDTA on Cu metabolism was studied by ip injection of CaNa2EDTA (2 ml 10% solution) to rats given sc 64Cu-labeled CuSO4. After 3 days, the Cu content of the blood, liver, kidney and intestines sharply decreased. The author concludes that prolonged use of EDTA would tend to deplete the body of Cu, and that prevention of Pb poisoning with EDTA is undesirable.]

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