2.

Uhl HSM, Brown HH, Zlatkis A, Zak, B, Myers GB, Boyle AJ. Effect of ethylenediamine-tetraacetic acid (EDT) on cholesterol metabolism in man. Preliminary report of effect of parenteral and oral administration of disodium and calcium salts. Am J Clin Pathol. 1953; 23:1226-1233. (CA48:2257d) [The effect of neutralized EDT on blood and hepatic cholesterol, Ca, Mg, and P was studied in a series of male rabbits given 1.0 g. of cholesterol daily and subdivided into 3 groups: (A) untreated controls, (B) animals receiving 500 mg. of Na EDT subcutaneously 3 to 5 times weekly, (C) animals receiving 3.0 g. of Na or Ca EDT by mouth daily. A fourth group received Na EDT in the same dosage as group B but were maintained on a stock diet without supplementary cholesterol. The blood cholesterol was significantly higher in groups B and C than that in A, but hepatic cholesterol was higher in A, and was normal in animals receiving supplementary EDT parenterally or orally. Animals maintained on a high-cholesterol diet alone for 111 days and then treated with EDT for 3 weeks showed normal hepatic cholesterol. These findings suggest that EDT not only may combat deposition of cholesterol in the liver, but may promote removal of stored cholesterol. The Ca and Mg content of the cholesterol-infiltrated livers of group A controls was significantly higher than that of uninfiltrated livers of rabbits treated with EDT. This, together with the demonstration of a higher Ca and Mg content of atheromatous aortas than in normal ones, suggests a possible interrelation of cholesterol, Ca, and Mg metabolism.]

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