Enhancement of Immunosurveillance
In Cancer Patients

T.Kobayashi,^1,2   T. Jo,²   S. Hayashida¹
1 Holistic Medical Clinic, Tokyo, Japan
2 Asia Medical Center, Oomiya City, Saitama 330, Japan

Abstract: It is believed that bioregulation of immune activity is performed by three factors: cytokines, thymic related substances, and cyclic nucleotides. From a study of adoptive immune (sensitized lymphocyte) therapy, fasting therapy, and their combination, it is demonstrated that a defective immune surveillance system in cancer patients exhibits basically abnormal levels of serum cyclic nucleotides. Abnormality in cyclic nucleotides was normalized by fasting therapy. This suggests that immunosurveillance in cancer patients was enhanced by fasting therapy.

It is well known that cancer patients exhibit a significant decrease in cellular immune activity which is related to the aggravation of the cancer.' It is thought that bioregulation of immune activity is performed by three factors: cytokines (monokine and lymphokine),2, 2 thymic hormones and related substances,4 and cyclic nucleotides.5-7 Which among these performs a central role in the immunosurveillance system?" Also, what does it mean to say that the occurrence of cancer is "an escape from the imunosurveillance system" ? We have already reported that by improving the immune activity of cancer patients 10,11 we also realized an improvement in the Ryodoraku charts, which reflect the activity of the autonomic nervous system. Particularly in cancer patients, a decrease in immune activity is readily apparent as the differences between the right and left Ryodoraku values.

These differences are thought to be based on abnormalities of the balance between the right and left cerebral hemispheres. 12 In addition, some researchers have conducted interesting investigations of the immune modulating center in the hypothalamus, 12-15 but what is it that regulates the mind, nerves, and immunity? We have investigated the relationship between Ryodoraku, immunity, and cyclic nucleotides which, we suggest, seem to play a central role in the immunosurveillance system. In this paper we report the levels of Ryodoraku, immune activity, and serum cyclic nucleotides in cancer patients who were treated with fasting therapy and/or adoptive immune (sensitized lymphocyte) therapy.

Materials and Methods

1. Ryodoraku Measurements: Ryodoraku was measured with a neurometer at 12 volts according to previously described methods. '°

2. Fasting Therapy: Food intake was gradually decreased for three days. On the day prior to commencement of the fasting therapy, a mixture of Aloe and lactulose (Lacdel, Suehiro Enzyme Institute, Osaka) was orally administered to purge the alimentary canal. Fasting therapy was carried out for three to seven days. After termination of the fasting